![]() BBB drug delivery is the limiting factor in the future development of new therapeutics for the brain. Biologics are large molecule therapeutics that do not cross the blood-brain barrier (BBB). Department of Medicine, University of California, Los Angeles, Los Angeles, CA, United StatesĪlzheimer’s disease (AD) and treatment of the brain in aging require the development of new biologic drugs, such as recombinant proteins or gene therapies.
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